How the Immune System Works,5/e > 소아과

How the Immune System Works has helped thousands of students understand what s in their big, thick, immunology textbooks. In his book, Dr. Sompayrac cuts through the jargon and details to reveal, in simple language, the essence of this complex subject. In fifteen easy-to-read chapters, featuring the humorous style and engaging analogies developed by Dr. Sompayrac, How the Immune System Works explains how the immune tem players work together to protect us from disease and, most importantly, why they do it this way. Rigorously d for this fifth edition, How the Immune System Works includes the latest information on subjects such as vaccines, the immunology of AIDS, and cancer. A highlight of this edition is a new chapter on the intestinal immune tem currently one of the hottest topics in immunology. Whether you are completely new to immunology, or require a refresher, How the Immune System Works will provide you with a clear and engaging overview of this fascinating subject. But don t take our word for it! Read what students have been saying about this classic book: "What an exceptional book! It''s clear you are in the hands of an expert." "Possibly the Best Small Text of All Time!" "This is a FUN book, and Lauren Sompayrac does a fantastic job of explaining the immune tem using words that normal people can understand." "Hands down the best immunology book I have read...a very enjoyable read." "This is simply one of the best medical textbooks that I have ever read. Clear diagrams coupled with highly readable text make this whole subject easily understandable and engaging." 

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Acknowledgments, vii

How to Use This Book, viii

This book is neither a comprehensive text nor an exam-review tool. It is an overview of the immune tem, designed to give anyone who is learning immunology a feel for how the tem fits together.

Lecture 1 An Overview, 1

The immune tem is a “team effort,” involving many different players who work together to provide a powerful defense against invaders. Focusing in on one player at a time makes it hard to understand the game. Here we view the action from the grandstands to get a wide-angle picture of what the immune tem is all about.

Lecture 2 The Innate Immune System, 13

The innate immune tem is a “hard-wired” defense that has evolved over millions of years to recognize pathogens that commonly infect humans. It provides a rapid and powerful response against “everyday” invaders.

Lecture 3 B Cells and Antibodies, 27

B cells and the antibodies they produce are part of the adaptive immune tem. This defense evolves during our own lifetime to protect us against invaders that we, personally, have never encountered before.

Lecture 4 The Magic of Antigen Presentation, 42

T cells, another weapon of the adaptive immune tem, only recognize invaders which are “properly presented” by specialized antigen presenting cells. This feature keeps these important cells focused on the particular attackers which they are able to def against.

Lecture 5 T Cell Activation, 55

Before they can spring into action, T cells must be activated. This requirement helps insure that only useful weapons will be mobilized.

Lecture 6 T Cells at Work, 63

Once they have been activated, helper T cells orchestrate the immune response, and er T cells destroy infected cells.

Lecture 7 Secondary Lymphoid Organs and Lymphocyte Trafficking, 72

B and T lymphocytes travel through secondary lymphoid organs looking for the intruders they can def against. Once activated in the secondary lymphoid organs, B and T cells are dispatched to the particular areas of the body where they can be most useful.

Lecture 8 Restraining the Immune System, 84

The powerful weapons of the immune tem must be restrained lest they become overexuberant. In addition, once an invader has been defeated, the immune tem must be “reset” to prepare for future attacks.

Lecture 9 Self Tolerance and MHC Restriction, 88

T cells must be trained to focus on appropriately presented invaders, and B and T lymphocytes must learn not to attack our own bodies.

Lecture 10 Immunological Memory, 98

The innate immune tem remembers pathogens which have been attacking humans for millions of years. In contrast, B and T cells remember pathogens we have encountered during our lifetime. Memory B and T lymphocytes respond more quickly and effectively to a subsequent attack by the same invader.

Lecture 11 The Intestinal Immune System, 103

The human intestines are home to trillions of bacteria, viruses, fungi, and parasites. How the immune tem deals with these potentially dangerous intestinal residents, which frequently invade the tissues surrounding the intestines, is a hot topic in immunology.

Lecture 12 Vaccines, 110

Vaccines safely mimic the attack of an invader so that our immune tem will be primed and ready for a future challenge by the same invader.

Lecture 13 The Immune System Gone Wrong, 116

The immune tem generally does a good job of defing us without causing a lot of “collateral damage.” Sometimes, however, mistakes are made.

Lecture 14 Immunodeficiency, 126

Serious disease may result when our immune tem does not operate at full strength. Humans who are infected with the AIDS virus have profoundly impaired immune tems.

Lecture 15 Cancer and the Immune System, 131

The human immune tem is not very good at defing us against cancer. Indeed, there is a built-in conflict between the need to minimize the chance that its weapons will attack our own bodies, and the need to destroy wannabe cancer cells.

Glossary, 139

Here are definitions of some of the terms that immunologists use – but which “normal” people wouldn’t.

List of Acronyms and Abbreviations, 142

Immunologists are big on acronyms and abbreviations, so I’ve made a list to which you can refer.

Index, 143