Offers definitive guidance on how to effectively manage the many health problems seen in newborn and premature infants.
Contains new chapters on Pathophysiology of Genetic Neonatal Disease, Genetic Variants and Neonatal Disease, and Developmental Biology of Lung Stem Cells, as well as significantly revised chapters on Cellular Mechanisms of Neonatal Brain Injury, Neuroprotective Therapeutic Hypothermia, Enteric Nervous System Development and Gastrointestinal Motility, and Physiology of Twin-Twin Transfusion.
Features 1,000 full-color diagrams, graphs and anatomic illustrations, 170+ chapters, and more than 350 global contributors.
Includes chapters devoted to clinical correlation that help explain the implications of fetal and neonatal physiology, as well as clinical applications boxes throughout.
Provides summary boxes at the end of each chapter and extensive cross-referencing between chapters for quick reference and review.
Allows you to apply the latest insights on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more.
Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Contents
Volume 1
Section I Genetics and Embryology
1 Basic Genetic Principles, 1
Haluk Kavus | Wendy K. Chung
2 Epigenetics, 11
William Schierding | Mark H. Vickers | Justin M. O’Sullivan | Wayne S. Cutfield
3 Basic Embryology, 23
David L. Bolender
4 Regulation of Embryogenesis, 38
Matt K. Lee | Changgong Li | David Warburton | Parviz Minoo
5 The Extracellular Matrix in Development, 47
Sandra L. Leibel | Martin Post
6 Angiogenesis, 54
Yalda Afshar | M. Luisa Iruela-Arispe
7 Prenatal Diagnosis, 58
Laura Smith | Barbara M. O’Brien
Section II Placenta and Intrauterine Environment
8 Placental Development, 67
Margaret G. Petroff | Helen Jones
9 Regulation of the Placental Circulation, 80
Imran N. Mir | Charles R. Rosenfeld
10 Mechanisms of Transfer Across the Human Placenta, 89
Rohan M. Lewis | Jane K. Cleal
11 Endocrine and Paracrine Function of the Human Placenta, 101
Anna A. Penn
12 Intra-Amniotic Infection/Inflammation and the Fetal Inflammatory Response Syndrome, 111
Eunjung Jung | Roberto Romero | Lami Yeo | Piya Chaemsaithong | Nardhy Gomez-Lopez
13 Fetal Origins of Adult Disease: A Classic Hypothesis With New Relevance, 129
Peter Russell Baker II
14 Placental Function in Intrauterine Growth Restriction, 137
Jill Chang | Karen Mestan
Section III Developmental Pharmacology
15 Basic Pharmacologic Principles, 150
Gabriel Altit | Julie Autmizguine | François Duhamel | Sylvain Chemtob
16 Principles of Pharmacokinetics, 166
Robert M. Ward | Kevin M. Watt | Steven E. Kern
17 The Physiology of Placental Drug Disposition, 173
Karel Allegaert | John Nicolaas van den Anker
18 Pharmacogenomics, 187
Laura B. Ramsey | Tomoyuki Mizuno | Alexander A. Vinks
19 Drug Distribution in Fetal Life, 194
Marianne Garland
20 Drug Transfer During Breastfeeding, 203
Thomas W. Hale | Kaytlin Krutsch
Section IV Intrauterine and Postnatal Growth
21 Placental and Fetal Circulatory and Metabolic Changes Accompanying Fetal Growth Restriction, 214
Barbra de Vrijer | Giacomo Meschia | Frederick C. Battaglia | Timothy R.H. Regnault | William W. Hay, Jr.
22 Endocrine Factors Affecting Neonatal Growth, 224
Kara Kuhn-Riordon | Yvonne K. Lee | Dennis M. Styne
23 Human Milk Composition and Function in the Infant, 241
Donna Geddes | Zoya Gridneva | Lisa Stinson | Peter Hartmann
24 Physiology of Lactation, 249
Jayne F. Martin Carli | Jenifer Monks | James L. McManaman
Section V Perinatal Iron, Mineral, and Vitamin Metabolism
25 Fetal and Neonatal Iron Metabolism, 257
Harry J. McArdle | Michael K. Georgieff
26 Fetal and Neonatal Calcium, Phosphorus, and Magnesium Homeostasis, 265
Karen M. O’Callaghan | Daniel E. Roth
27 Zinc in the Fetus and Neonate, 282
Nancy F. Krebs | K. Michael Hambidge
28 Vitamin A Metabolism in the Fetus and Neonate, 287
Libo Tan | A. Catharine Ross
29 Vitamin E Nutrition in Pregnancy and the Newborn Infant, 295
Karla Danielly da S. Ribeiro | Débora Gabriela Fernandes Assunção | Natália Carlos Maia Amorim | Priscila Gomes de Oliveira
30 Vitamin K Metabolism in the Fetus and Neonate, 303
Martin J. Shearer | Paul Clarke
Section VI Lipid Metabolism
31 Maternal-Fetal Transfer of Lipid Metabolites, 311
Emilio Herrera | Miguel Angel Lasunción
32 Brown Adipose Tissue: Development and Function, 323
Jan Nedergaard | Barbara Cannon
33 Lipids as an Energy Source for the Premature and Term Neonate, 332
Emilio Herrera | Henar Ortega-Senovilla
34 Ketone Body Metabolism in the Neonate, 339
Baris Ercal | Peter A. Crawford
35 Long-Chain Polyunsaturated Fatty Acids in Neurodevelopment, 348
Kathleen M. Gustafson | John Colombo | Susan E. Carlson
Section VII Carbohydrate Metabolism
36 Glucose Metabolism in the Fetus and Newborn, and Methods for Its Investigation, 358
Sarah A. Wernimont | Andrew W. Norris
37 Oxygen Consumption and General Carbohydrate Metabolism of the Fetus, 368
Anthony F. Philipps
38 Role of Glucoregulatory Hormones in Hepatic Glucose Metabolism During the Perinatal Period, 382
Kathryn Beardsall | Amanda Ogilvy-Stuart | Myat Su Win
39 Cell Glucose Transport and Glucose Handling During Fetal and Neonatal Development, 392
Rebecca A. Simmons
Section VIII Protein Metabolism
40 General Concepts of Protein Metabolism, 400
Chris H.P. van den Akker | Johannes (Hans) B. van Goudoever | Dwight E. Matthews
41 Placental Transfer and Fetal Requirements of Amino Acids, 408
Laura D. Brown | Rohan M. Lewis | William W. Hay, Jr. | Timothy R.H. Regnault
Section IX Thermoregulation
42 Temperature Control in Newborn Infants, 423
Rakesh Sahni
Section X Skin
43 Structure and Development of the Skin and Cutaneous Appendages, 446
David H. Chu | Cynthia A. Loomis
44 Physiologic Development of the Skin, 454
Marty O. Visscher | Vivek Narendran
Section XI Fetal and Neonatal Cardiovascular Physiology
45 Cardiovascular Development, 473
Maurice J.B. van den Hoff | Andy Wessels
46 Developmental Electrophysiology in the Fetus and Neonate, 482
Janette F. Strasburger | Annette Wacker-Gussmann | Michael A. Schellpfeffer
47 Developmental Biology of the Pulmonary Vasculature, 501
Cristina M. Alvira | Shazia Bhombal | Marlene Rabinovitch
48 Development of the Gastrointestinal Circulation in the Fetus and Newborn, 517
Upender K. Munshi | David A. Clark
49 Physiology of Congenital Heart Disease in the Neonate, 521
†Thomas J. Kulik | Philip T. Levy
50 Regulation of Cardiovascular Function During Fetal and Newborn Life, 534
Dino A. Giussani | Jeffrey L. Segar
51 Nutritional and Environmental Effects on the Fetal Circulation, 545
Lucy R. Green | Mark A. Hanson †Deceased.
52 Mechanisms Regulating Closure of the Ductus Arteriosus, 553
Ronald I. Clyman
53 Umbilical Circulation, 564
Torvid Kiserud | Guttorm Haugen
54 Fetal and Placental Circulation During Labor, 576
Karel Maršál
Section XII The Lung
55 Normal and Abnormal Structural Development of the Lung, 585
Xin Sun
56 Regulation of Alveolarization, 600
Christophe Delacourt | Alice Hadchouel
57 Physiologic Mechanisms of Normal and Altered Lung Growth Before and After Birth, 605
Megan J. Wallace | Stuart B. Hooper | Richard Harding
58 Molecular Mechanisms of Lung Development and Lung Branching Morphogenesis, 617
Sandra L. Leibel | Martin Post
59 Regulation of Liquid Secretion and Absorption by the Fetal and Neonatal Lung, 626
David P. Carlton
60 Upper Airway Structure: Function, Regulation, and Development, 635
Thomas H. Shaffer | Raymond B. Penn | Marla R. Wolfson
61 Regulation of Lower Airway Function, 645
Abhrajit Ganguly | Richard J. Martin | Peter M. MacFarlane | Y.S. Prakash | Thomas M. Raffay
62 Functional Development of Respiratory Muscles, 652
Carlos B. Mantilla | Joline E. Brandenburg | Matthew J. Fogarty | Gary C. Sieck
63 Mechanics of Breathing, 665
Jacopo P. Mortola
64 Pulmonary Gas Exchange in the Developing Lung, 673
Leif D. Nelin | John P. Kinsella | William E. Truog III
65 Oxygen Transport and Delivery, 684
Danielle R. Rios | Afif F. El-Khuffash | Patrick J. McNamara
66 Control of Breathing in Fetal Life and Onset and Control of Breathing in the Neonate, 697
Ruben E. Alvaro
67 Basic Mechanisms of Oxygen Sensing and Adaptation to Hypoxia, 707
Dan Zhou | Gabriel G. Haddad
68 Evaluation of Pulmonary Function in the Neonate, 714
Emidio Sivieri | Kevin Dysart | Soraya Abbasi | Eric C. Eichenwald
69 Mechanisms of Neonatal Lung Injury, 728
Anastasiya Mankouski | Richard Lambert Auten, Jr.
70 Impaired Lung Growth After Injury in Preterm Lung, 734
Kurt H. Albertine | Theodore J. Pysher | Bradley A. Yoder
71 Antenatal Factors That Influence Postnatal Lung Development and Injury, 748
Suhas G. Kallapur | Alan H. Jobe
72 Regulation of Pulmonary Circulation, 757
Yuansheng Gao | J. Usha Raj
SECTION XIII Surfactant
73 Historical Perspective, 765
John A. Clements
74 Developmental Biology of Lung Stem Cells, 768
Ivana Mi?íková | Chanèle Cyr-Depauw | Bernard Thébaud
75 Surfactant Homeostasis: Composition and Function of Pulmonary Surfactant Lipids and Proteins, 776
Jeffrey A. Whitsett | Paul S. Kingma
76 Structure and Development of Alveolar Epithelial Cells, 787
Henry J. Rozycki | Karen D. Hendricks-Muñoz
77 Regulation of Surfactant-Associated Phospholipid Synthesis and Secretion, 792
Wolfgang Bernhard
78 Antenatal Hormonal Therapy for Prevention of Respiratory Distress Syndrome, 804
J.E. Harding | C.A. Crowther | C.J.D. McKinlay
79 Surfactant Treatment, 813
Alan H. Jobe | Suhas G. Kallapur
80 Genetics and Physiology of Surfactant Protein Deficiencies, 825
Jennifer A. Wambach | Lawrence M. Nogee
SECTION XIV Physiology of Gastrointestinal Tract in the Fetus and Neonate
81 Trophic Factors and Regulation of Gastrointestinal Tract and Liver Development, 838
Douglas G. Burrin | Caitlin E. Vonderohe
Organogenesis of the Gastrointestinal Tract, 845
Maxime M. Mahe | Michael A. Helmrath | Noah F. Shroyer
83 Development of Gastric Secretory Function, 854
Joshua D. Prozialeck | Barry K. Wershil
84 Development of the Enteric Nervous System and Gastrointestinal Motility, 859
Julie Khlevner | Andrew Del Colle | Kara Gross Margolis
85 Development of the Endocrine and Exocrine Pancreas, 868
Lori Sussel
86 Digestive-Absorptive Functions in Fetuses, Infants, and Children, 881
Diomel de la Cruz | Josef Neu
87 The Developing Microbiome of the Fetus and Neonate: A Multiomic Approach, 888
Josef Neu | Neel Kamal Singh
SECTION XV Liver and Bilirubin Metabolism
88 Organogenesis and Histologic Development of the Liver, 896
Steven Lobritto
89 Bile Acid Metabolism During Development, 901
Linda X. Wang | Rohit Kohli
90 Fetal and Neonatal Bilirubin Metabolism, 915
Ryoichi Fujiwara
91 Hereditary Contributions to Neonatal Hyperbilirubinemia, 919
Michael Kaplan | Cathy Hammerman
92 Mechanistic Aspects of Phototherapy for Neonatal Hyperbilirubinemia, 930
Vinod K. Bhutani | Christina M. Konecny | Ronald J. Wong
Volume 2
Section XVI The Kidney
93 Development of the Kidney: Morphology and Mechanisms, 941
Ian M. Smyth | Luise A. Cullen-McEwen | Alexander N. Combes | Lori L. O’Brien | Mary Jane Black | John F. Bertram
94 Functional Development of the Kidney in Utero, 954
Douglas G. Matsell | Michael J. Hiatt
95 Development and Regulation of Renal Blood Flow in the Neonate, 965
Michael J. Solhaug | Pedro A. Jose
96 Postnatal Development of Glomerular Filtration Rate in Neonates, 975
Jean-Pierre Guignard | Silvia Iacobelli
97 Renal Transport of Sodium During Development, 984
Michel Baum
98 Potassium Homeostasis in the Fetus and Neonate, 992
Matthias T. Wolf | Corinne Benchimol | Lisa M. Satlin | Raymond Quigley
99 Role of the Kidney in Calcium and Phosphorus Homeostasis, 1006
Minh Dien Duong | Frederick J. Kaskel
100 Transport of Amino Acids in the Fetus and Neonate, 1018
Raymond Quigley
101 Organic Anion Transport in the Developing Kidney, 1024
Sun-Young Ahn | Jeremiah D. Momper | Sanjay K. Nigam
102 Concentration and Dilution of Urine, 1030
Silvia Iacobelli | Jean-Pierre Guignard
103 Urinary Acidification, 1047
Seth L. Alper | George J. Schwartz
104 Response to Nephron Loss in Early Development, 1056
Pamela I. Good | Fangming Lin | Jennifer R. Charlton
SECTION XVII Fluid and Electrolyte Metabolism
105 Fluid Distribution in the Fetus and Neonate, 1064
Chang-Ryul Kim | Barbara S. Stonestreet
106 Regulation of Acid-Base Balance in the Fetus and Neonate, 1076
Timur Azhibekov | Philippe S. Friedlich | Istvan Seri
Section XVIII Developmental Hematopoiesis
107 Developmental Biology of Hematopoietic Stem Cells, 1082
Amélie Collins
108 Neutrophil Granulopoiesis and Homeostasis, 1093
Shelley M. Lawrence | Victor Nizet
109 Developmental Erythropoiesis, 1104
Timothy M. Bahr | Robin K. Ohls
110 Developmental Megakaryopoiesis, 1125
Martha C. Sola-Visner | Patricia Davenport
Section XIX Hemostasis
111 Developmental Hemostasis, 1145
Paul Monagle
112 Platelet–Vessel Wall Interactions, 1153
Thomas G. Diacovo
Section XX Developmental Immunobiology
113 Host Defense Mechanisms Against Bacteria, 1158
Tobias R. Kollmann | Nicolas Dauby | Danny Harbeson | Mario Fidanza | Arnaud Marchant
114 Host Defense Mechanisms Against Fungi, 1167
Melinda Erdos | László Maródi
115 Host Defense Mechanisms Against Viruses, 1172
James E. Crowe, Jr. | Fabienne Willems | Arnaud Marchant
116 T-Cell Development, 1195
Melinda Erdos | László Maródi
117 B-Cell Development, 1200
Sandra C.A. Nielsen | Scott D. Boyd
118 Mononuclear Phagocyte System, 1206
Pascal M. Lavoie | Ofer Levy
119 Normal and Abnormal Neutrophil Physiology in the Newborn, 1215
Joyce M. Koenig | Joseph M. Bliss | Markus Sperandio
120 The Complement System of the Fetus and Newborn, 1232
Melvin Berger
121 Cytokines and Inflammatory Response in the Fetus and Neonate, 1243
Scott M. Gordon | Lakshmi Srinivasan | Mary Catherine Harris | Laurie E. Kilpatrick
122 Immunology of Human Milk, 1257
Armond S. Goldman | Sadhana Chheda | Susan E. Keeney
123 Neonatal Pulmonary Host Defense, 1265
Misty Good | Jay K. Kolls | Kerry M. Empey
Section XXI Neurology
124 Development of the Nervous System, 1297
Christopher J. Yuskaitis | Scott L. Pomeroy
125 Mechanisms of Cell Death in the Developing Brain, 1318
Claire Thornton
126 Development of the Blood-Brain Barrier, 1327
Clémence Disdier | Susan S. Cohen | Mariella
Errede | Daniela Virgintino | Barbara S. Stonestreet
127 Trophic Factor, Nutritional, and Hormonal Regulation of Brain Development, 1341
David Pleasure
128 Developmental Aspects of Pain, 1347
Manon Ranger | Simon Beggs | Ruth E. Grunau
129 Cerebellar Development—The Impact of Preterm Birth and Comorbidities, 1353
Emily W.Y. Tam | Manon J.N.L. Benders | Vivi M. Heine
130 Electroencephalography in the Preterm and Term Infant, 1367
Maria Roberta Cilio | Francesco Pisani
131 Intraventricular Hemorrhage in the Neonate, 1394
Brian H. Walsh | Terrie E. Inder
132 Pathophysiology of Neonatal White Matter Injury, 1414
Steven P. Miller | Stephen A. Back
133 Cellular and Molecular Mechanisms of Neonatal Brain Injury and Neuroprotection, 1422
Panagiotis Kratimenos | Joseph Scafidi | Vittorio Gallo
134 Neuroprotective Therapeutic Hypothermia, 1432
Alistair J. Gunn | Joanne O. Davidson | Laura Bennet
Section XXII Special Sensory Systems in the Fetus and Neonate
135 Early Development of the Human Auditory System, 1440
Kelsey L. Anbuhl | Kristin M. Uhler | Lynne A. Werner | Daniel J. Tollin
136 Development of Olfaction and Taste in the Human Fetus and Neonate, 1455
Harvey B. Sarnat
Section XXIII Musculoskeletal
137 The Growth Plate: Embryologic Origin, Structure, and Function, 1465
Emmanouil Grigoriou | John P. Dormans
138 Ontogenesis of Striated Muscle, 1475
Harvey B. Sarnat
Section XXIV Endocrine Function
139 Hypothalamus: Neuroendometabolic Center, 1495
Adda Grimberg | Jessica Katz Kutikov
140 Growth Factor Regulation of Fetal Growth, 1505
Colin P. Hawkes | Lorraine E. Levitt Katz
141 Growth Hormone, Prolactin, and Placental Lactogen in the Fetus and Newborn, 1514
Nursen Gurtunca | Mark A. Sperling
142 Luteinizing Hormone and Follicle-Stimulating Hormone Secretion in the Fetus and Newborn Infant, 1520
Sumana Narasimhan | Ethel G. Clemente | Neha V. Vyas | T. Rajendra Kumar
143 Development of the Hypothalamus-Pituitary- Adrenal Axis in the Fetus, 1532
Brian J. Feldman | Abby Walch | Jennifer Zabinsky
144 Fetal and Neonatal Adrenocortical Physiology, 1538
Kristi L. Watterberg | Louis J. Muglia
145 Fetal and Neonatal Thyroid Physiology, 1546
Andrew J. Bauer
Section XXV Ovary and Testis
146 Genetics of Sex Determination and Differentiation, 1555
Peter James Ivor Ellis
147 Differentiation of the Ovary, 1566
Linn Salto Mamsen | Claus Yding Andersen | Andrew J. Childs | Richard A. Anderson
148 Testicular Development and Descent, 1574
Mary M. Lee
Section XXVi PAT HOPHYSIOLOGY OF NEONATAL DISEASES
149 The Pathophysiology of Twin-Twin Transfusion Syndrome, Twin-Anemia Polycythemia Sequence, and Twin-Reversed Arterial Perfusion, 1582
Christoph Wohlmuth
150 Physiology of Neonatal Resuscitation, 1589
Stuart B. Hooper | Arjan B. te Pas
151 Pathophysiology of Neonatal Sepsis, 1606
James L. Wynn
152 Pathophysiology of Neonatal Hypoglycemia, 1624
Colin P. Hawkes | Diana E. Stanescu | Charles A. Stanley
153 Pathophysiology of Cardiomyopathies, 1633
Hugo R. Martinez | Thomas D. Ryan | Jeffrey A. Towbin
154 Pathophysiology of Persistent Pulmonary Hypertension of the Newborn, 1648
Satyan Lakshminrusimha | Robin H. Steinhorn
155 Pathophysiology of Shock in the Fetus and Neonate, 1662
Shahab Noori | Philippe S. Friedlich | Istvan Seri
156 Pathophysiology of Apnea of Prematurity, 1671
Lisa J. Mitchell | Peter M. MacFarlane | Ryan W. Bavis | Richard J. Martin
157 Pathophysiology of Respiratory Distress Syndrome, 1680
Alan H. Jobe
158 Pathophysiology of Meconium Aspiration Syndrome, 1696
Jason Gien | John P. Kinsella
159 Pathophysiology of Bronchopulmonary Dysplasia, 1703
Eduardo H. Bancalari | Deepak Jain
160 Pathophysiology of Ventilator-Dependent Infants, 1710
Howard B. Panitch
161 Pathophysiology of Gastroesophageal Reflux, 1722
Sudarshan Rao Jadcherla
162 Pathophysiology and Prevention of Neonatal Necrotizing Enterocolitis, 1732
Misty Good | Michael Caplan
163 Pathophysiology of Kernicterus, 1738
Thor Willy Ruud Hansen
164 Pathophysiology of Neonatal Acute Kidney Injury, 1750
David T. Selewski | David J. Askenazi | Jennifer R. Charlton | Jennifer G. Jetton
165 Pathophysiology of Edema, 1760
David P. Carlton
166 Pathophysiology of Retinopathy of Prematurity, 1765
M. Elizabeth Hartnett
167 Pathophysiology of Neonatal Hypoxic-Ischemic Brain Injury, 1773
Vadim S. Ten
168 Pathophysiology of Neonatal Acute Bacterial Meningitis, 1784
Rodrigo Hasbun | Allan Collodel | Tatiana Barichello
169 Pathophysiology of Neural Tube Defects, 1797
Andrew J. Copp | Nicholas D.E. Greene
170 Pathophysiology of Preeclampsia, 1811
Sarosh Rana | S. Ananth Karumanchi
171 Pathophysiology of Preterm Birth, 1820
David A. MacIntyre | Shirin Khanjani | Phillip R. Bennett
172 Pathophysiology of Chorioamnionitis: Host Immunity and Microbial Virulence, 1828
Thomas A. Hooven | Tara M. Randis
173 Pathophysiology of Genetic Neonatal Disease, 1837
Katrina A. Andrews | Sarah A. Bowdin
174 Genetic Variants and Neonatal Disease, 1846
Jennifer L. Cohen | C. Michael Cotten
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