Fundamentals of Toxicologic Pathology, Third Edition, presents an essential overview of systems toxicologic pathology in a clear-and-concise manner. Toxicologic pathology integrates toxicology and its interdisciplinary components, including biochemistry, pharmacodynamics and risk assessment to pathology and its related disciplines, such as physiology, microbiology, immunology and molecular biology. This wholly revised and updated edition presents the newest information on the topic, and is an essential reference for advanced students, early career researchers, toxicologic pathologists, pharmaceutical scientists, medical pathologists and clinicians, and anyone involved with drug and device development. The book includes a new section describing the application of toxicologic pathology, such as diagnostic and forensic toxicologic pathology, environmental toxicologic pathology, experimental and industrial toxicologic pathology, and pathology issues in the design of toxicology studies. There are also new chapters on special senses (the eye and ear) and the biochemical and molecular basis of toxicity, among others.
Key Features
1. Overview of Toxicological Pathology
Part I: Principles of Toxicologic Pathology
2. Biochemical and Molecular Basis of Toxicity
3. Pharmacokinetics &; Toxicokinetics
4. Principles of Pharmacodynamics &; Toxicodynamics
5. Morphologic Manifesations of Toxic Cell Injury
6. Carcinogenesis: Mechanisms and Manifestation
7. Design of Studies &; Risk Management in Toxicologic Pathology
Part II: Systems Toxicologic Pathology
8. Hepatobiliary System
9. Cardiovascular System
10. Muscular System
11. Urinary System
12. Immune System
13. Hematopoietic System
14. Respiratory Tract
15. Digestive Tract
16. Exocrine Pancreas
17. Male Reproductive System
18. Female Reproductive System
19. Mammary Gland
20. Endocrine System
21. Nervous System
22. Special Senses: Ocular Sytem
22b. Special Senses: Auditory System
23. Skeletal System (Bone &; Joint)
24. Integumentary System
25. Embryo, Fetus &; Placenta
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