Molecular Imaging: Principles and Practice 2e > Cardiac

The detection and measurement of the dynamic regulation and interactions of cells and proteins within the living cell are critical to the understanding of cellular biology and pathophysiology. The multidisciplinary field of molecular imaging of living subjects continues to expand with dramatic advances in chemistry, molecular biology, therapeutics, engineering, medical physics and biomedical applications. Molecular Imaging: Principles and Practice, Volumes 1 and 2, Second Edition provides the first point of entry for physicians, scientists, and practitioners. This authoritative reference book provides a comprehensible overview along with in-depth presentation of molecular imaging concepts, technologies and applications making it the foremost source for both established and new investigators, collaborators, students and anyone interested in this exciting and important field.

Key Features

The most authoritative and comprehensive resource available in the molecular-imaging field, written by over 170 of the leading scientists from around the world who have evaluated and summarized the most important methods, principles, technologies and data
Concepts illustrated with over 600 color figures and molecular-imaging examples
Chapters/topics include, artificial intelligence and machine learning, use of online social media, virtual and augmented reality, optogenetics, FDA regulatory process of imaging agents and devices, emerging instrumentation, MR elastography, MR fingerprinting, operational radiation safety, multiscale imaging and uses in drug development
This edition is packed with innovative science, including theranostics, light sheet fluorescence microscopy, (LSFM), mass spectrometry imaging, combining in vitro and in vivo diagnostics, Raman imaging, along with molecular and functional imaging applications
Valuable applications of molecular imaging in pediatrics, oncology, autoimmune, cardiovascular and CNS diseases are also presented
This resource helps integrate diverse multidisciplinary concepts associated with molecular imaging to provide readers with an improved understanding of current and future applications

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• Volume 1
  Overview
  1. General Principles of Molecular Imaging
  Brian D. Ross and Sanjiv Sam Gambhir
  Part I: Molecular Imaging Technologies
  2. Positron Emission TomographyeMagnetic Resonance Imaging
  Farshad Moradi, Ryan L. Brunsing, Vipul R. Sheth and Andrei Iagaru
  3. SPECT and SPECT/CT
  Brian F. Hutton, Marlies C. Goorden and Freek J. Beekman
  4. Principles of Micro X-ray Computed Tomography
  Cristian T. Badea
  5. Small-Animal SPECT, SPECT/CT, and SPECT/MRI
  Ling-Jian Meng and Neal H. Clinthorne
  6. Instrumentation and Methods to Combine Small-Animal PET With Other Imaging Modalities
  Andrew N. Groll and Craig S. Levin
  7. Functional Imaging Using Bioluminescent Reporter Genes in Living Subjects
  Scott K. Lyons, Kevin P. Francis and Christopher H. Contag
  8. Principles and Practice of Intraoperative Fluorescence Imaging
  Dimitris Gorpas, Vasilis Ntziachristos and Jie Tian
  9. Molecular Endoscopic Imaging in Cancer
  Timo Rath, Markus F. Neurath and Raja Atreya
  10. Intravital Microscopy
  Shariq M. Usmani and Thorsten R. Mempel
  11. Ultrasound
  F. Stuart Foster and Emmanuel Cherin
  12. Hybrid PET-CT-Ultrasound Imaging
  Bertrand Tavitian and Mailyn Perez-Liva
  13. Photoacoustic Molecular Imaging: Principles and Practice
  Junjie Yao and Lihong V. Wang
  14. Inhaled Gas Magnetic Resonance Imaging: Advances, Applications, Limitations, and New Frontiers
  Alexander M. Matheson, Caleb Thompson and Grace Parraga
  15. Magnetic Particle Imaging for Vascular, Cellular and Molecular Imaging
  Prashant Chandrasekharan, Zhi Wei Tay, Xinyi Y. Zhou, Elaine Y. Yu, Barry K.L. Fung, Caylin Colson, Benjamin D. Fellows, Yao Lu, Quincy Huynh, Chinmoy Saayujya, Paul Keselman, Daniel Hensley, Kuan Lu, Ryan Orendorff, Justin Konkle, Emine Ulku Saritas, Bo Zheng, Patrick Goodwill and Steven Conolly
  16. Optogenetics
  Maria G. Paez Segala and Loren L. Looger
  17. Imaging Mass Spectrometry
  Richard R. Drake, Danielle A. Scott and Peggi M. Angel
  18. CEST (Chemical Exchange Saturation Transfer) MR Molecular Imaging
  Guanshu Liu and Peter C.M. van Zijl
  19. Molecular Imaging Using Raman Scattering
  Stefan Harmsen and Sanjiv Sam Gambhir
  20. Synchrotron-Based Dynamic Lung Imaging
  Stephen Dubsky
  21. Light-Sheet Fluorescence Microscopy for Multiscale Biological Imaging
  Jae-Byum Chang, Ruixuan Gao and Fei Chen
  22. Cerenkov Imaging
  Edwin C. Pratt, Ryo Tamura and Jan Grimm
  23. Near-Infrared II Optical Imaging
  Shuqing He and Zhen Cheng
  Part II: Chemistry of Molecular Imaging
  24. Chemistry of Molecular Imaging: An Overview
  Silvio Aime, Fabio Travagin, Enzo Terreno and Giovanni B. Giovenzana
  25. PET Radiochemistry
  Henry F. VanBrocklin
  26. SPECT Radiochemistry
  Theodosia Maina and Mathew Thakur
  27. The Chemistry in Surface Functionalization of Nanoparticles for Molecular Imaging 493
  Xianchuang Zheng, Joanna Wang and Jianghong Rao
  28. Newer Bioconjugation Methods
  Ahmet Krasniqi, Catarina Xavier and Nick Devoogdt
  29. Targeted Antibodies and Peptides
  Michael R. Lewis, Cathy S. Cutler and Silvia S. Jurisson
  30. Antibody-Based Molecular Imaging
  Kathryn M. Tully, Veronica L. Nagle, Joshua A. Korsen and Jason S. Lewis
  31. Hyperpolarized Magnetic Resonance With Dissolution Dynamic Nuclear Polarization: Principles and Applications
  Jan H. Ardenkjaer-Larsen
  32. Magnetic Resonance Imaging Agents
  Cuihua Wang, Elisenda Rodriguez and John W. Chen
  33. Optical Imaging Agents
  Luisa Ottobrini, Cristina Martelli and Giovanni Lucignani
  34. Photoacoustic Molecular Imaging With Exogenous Agents
  Liming Nie, Yajing Liu and Xiaogyuan Chen
  35. Ultrasound Contrast Agents
  Mark A. Borden, Paul A. Dayton, Connor Slagle and Rachel W. Walmer
  36. Theranostics: Agents for Diagnosis and Therapy
  Fay Nicolson and Moritz F. Kircher
  37. Magnetic Nanoparticles
  Ahmad Amirshaghaghi, Zhiliang Cheng, Lee Josephson and Andrew Tsourkas
  38. Aptamers for Molecular Imaging
  Fre´de´ric Duconge´
  39. Nonclinical Product Developmental Strategies, Safety Considerations and Toxicity Profiles of Medical Imaging and Radiopharmaceuticals Products
  Adebayo Laniyonu, Yanli Ouyang, Jonathan Cohen, Sunny Awe, Olayinka Dina, Siham Biade, Sally Hargus and Tushar Kokate
  40. Intraoperative Molecular Imaging Agents
  Stan van Keulen and Eben L. Rosenthal

  Volume 2
  Part III: Molecular Imaging in Cell and Molecular Biology
  41. Protein Engineering for Molecular Imaging
  Anna M. Wu
  42. Phage Display for Imaging Agent Development
  Jessica Hung, Fred Reynolds and Kimberly A. Kelly
  43. Molecular Imaging of Gene Therapy
  Ramasamy Paulmurugan and Tarik F. Massoud
  44. Cell Surveillance Using Magnetic Resonance Imaging
  Brooke M. Helfer and Jeff W.M. Bulte
  45. Tumor Vasculature
  Susan Notohamiprodjo, Zohreh Varasteh, Ambros J. Beer, Gang Niu, Xiaoyuan (Shawn) Chen, Wolfgang Weber and Markus Schwaiger
  46. Imaging Hypoxia
  Hong Yuan, Gregory M. Palmer and Mark W. Dewhirst
  47. Molecular Imaging of ProteineProtein Interactions and Protein Folding
  Tarik F. Massoud and Ramasamy Paulmurugan
  48. Molecular Imaging of Cellular Signaling Pathways
  Kathryn E. Luker
  49. Exosome Imaging
  Do Won Hwang, Minseok Suh and Dong Soo Lee
  50. Gene-Editing Technologies and Applications for Molecular Imaging
  Gary D. Luker
  51. Reporter Genes for Ultrasound and MRI
  Mikhail G. Shapiro
  52. Theranostic Approaches Using Live Bacteria
  Jung-Joon Min, Mai Thi-Quynh Duong, Thangam Ramar, Sung-Hwan You and Sae-Ryung Kang
  Part IV: Applications of Molecular Imaging Oncology
  53. Molecular and Functional Imaging and Theranostics of the Tumor Microenvironment
  Marie-France Penet, Samata Kakkad, Jesus Pacheco-Torres, Santosh Bharti, Balaji Krishnamachary and Zaver M. Bhujwalla
  54. Novel Magnetic Resonance Imaging and Positron Emission Tomography in the RT Planning and Assessment of Response of Malignant Gliomas
  David Kamson and Christina Tsien
  55. PET Diagnosis and Response Monitoring in Oncology
  Richard L. Wahl and Rodney J. Hicks
  56. Spectroscopic MRI for Brain Tumor Imaging
  Hyunsuk Shim
  57. Cancer Detection and Quantification of Treatment Response Using Diffusion-Weighted MRI
  Brian D. Ross and Thomas L. Chenevert
  58. Prostate Cancer Theranostics
  Steven P. Rowe, Mohammad S. Sadaghiani, Rudolf A. Werner, Takahiro Higuchi, Thorsten Derlin, Lilja B. Solnes and Martin G. Pomper
  59. Pediatric Molecular Imaging
  Heike E. Daldrup-Link
  Cardiovascular
  60. Imaging Myocardial Metabolism
  Robert J. Gropler
  61. Congestive Heart Failure
  Stephan G. Nekolla, Antti Saraste, Hendrik Sager, Marcus R. Makowski and Markus Schwaiger
  62. Molecular Imaging of Atherosclerosis
  Eric A. Osborn, Mazen Albaghdadi, Peter Libby and Farouc A. Jaffer
  63. Thrombosis and Embolism
  Reza Hajhosseiny, Claudia Prieto, Haikun Qi, Alkystis Phinikaridou and Rene´ M. Botnar
  64. Molecular Imaging of Stem Cell Therapy in Ischemic Cardiomyopathy
  Mark Chandy and Joseph C. Wu
  Central Nervous System
  65. Central Nervous System Molecular Imaging
  Lilja B. Solnes, Andreas H. Jacobs, Jennifer M. Coughlin, Yong Du, Reema Goel, Dima A. Hammoud and Martin G. Pomper
  66. Applications, Advances, and Limitations of Molecular Imaging of Brain Receptors
  Paul Cumming, Gerhard Gru¨nder, Zabecca Brinson and Dean F. Wong
  67. PET and SPECT Imaging of Neurodegenerative Diseases
  Alexander Drzezga, Ge´rard N. Bischof, Kathrin Giehl and Thilo van Eimeren
  68. PET Imaging of Neuroinflammation
  Aisling M. Chaney, Emily M. Deal, Isaac M. Jackson and Michelle L. James
  Autoimmunity and Immunology
  69. Identifying Musculoskeletal Pain Generators Using Molecular Imaging
  Daehyun Yoon, Feliks Kogan, Garry Gold and Sandip Biswal
  70. Molecular Imaging of Autoimmune Diseases
  Alberto Signore, Arianna Di Paolo and Filippo Galli
  71. Molecular Imaging of Diabetes
  Lieke Joosten, Marti Boss, Tom Jansen, Maarten Brom, Mijke Buitinga, Erik Aarntzen, Olof Eriksson, Lars Johansson, Bastiaan de Galan and Martin Gotthardt
  72. Imaging in Asthma
  Avanti Gulhane and Delphine L. Chen
  73. Molecular Imaging of Fibrosis
  Iris Y. Zhou, Sydney B. Montesi, Eman A. Akam and Peter Caravan
  74. Imaging of Bacterial Infections
  Alvaro A. Ordon˜ez and Sanjay K. Jain
  Part V: Molecular Imaging in Drug Evaluation
  75. Molecular and Functional Imaging in Central Nervous System Drug Development
  Basil Ku¨nnecke, Michael Honer, Gennaro Pagano and Markus Rudin
  76. PET Imaging in Cancer Clinical Trials
  David A. Mankoff
  77. Magnetic Resonance Imaging: Cardiovascular Applications for Clinical Trials
  Chun Yuan, Zach Miller and Xue-Qiao Zhao
  78. Imaging of Gene and Cell-Based Therapies: Basis and Clinical Trials
  Andreas H. Jacobs, Sonja Schelhaas, Thomas Viel, Yannic Waerzeggers, Alexandra Winkeler, Bastian Zinnhardt and Juri Gelovani
  Part VI: Image Quantitation/Analytics
  79. Virtual and Augmented Reality Technologies in Molecular and Anatomical Imaging
  Suman B. Mondal and Samuel Achilefu
  80. Quantification of Radiotracer Uptake Into Tissue
  Michael M. Graham
  81. Pharmacokinetic Modeling
  Sung-Cheng (Henry) Huang
  82. Online Social Media: Concepts and Practices for Molecular Imaging Professionals
  Chadwick L. Wright, Michelle I. Knopp and Michael V. Knopp
  83. The Regulatory Process for Imaging Agents and Devices
  Matthew F. Covington, Sally W. Schwarz and John M. Hoffman
  84. Operational Radiation Safety for PET-CT, SPECT-CT, and Cyclotron Facilities
  Pat Zanzonico
  85. Bridging Spatial Scales From Radiographic Images to Cellular and Molecular Properties in Cancers
  Natarajan Raghunand and Robert A. Gatenby
  86. AI/Machine Learning in Medical Imaging
  Maryellen L. Giger
  87. Retrospective Registration in Molecular Imaging
  Brian D. Ross, Thomas L. Chenevert and Charles R. Meyer
  88. Image Processing Analytics: Enhancements and Segmentation
  Lubomir Hadjiiski, Ravi Samala and Heang-Ping Chan
  89. Magnetic Resonance Fingerprinting: Basic Concepts and Applications in Molecular Imaging
  Kathleen Ropella-Panagis and Nicole Seiberlich
  90. MR Elastography
  Patrick J. Navin, Sudhakar Kundapur Venkatesh and Richard L. Ehman